https://www.jacewjoneslab.com/contact daily 0.75 2025-05-20 https://www.jacewjoneslab.com/publications daily 0.75 2025-05-20 https://www.jacewjoneslab.com/lab-members daily 0.75 2025-05-21 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1609188715031-GCGIV5BJZWAD8TE06Q3T/jwj.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1ef82e5c-f29d-448f-8186-8dab327d9f7f/JYY.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/2e8299e9-d3be-498f-9509-df89a66aa2df/Sazia_photo_updated.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/a7c44f74-4cdd-410b-9133-ebdf609b13a6/Josie+Daldegan_headshot_2023.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/6bdeb168-16a7-4166-884f-3e4cefabdd14/1000034581.jpg https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1d064cd3-46f8-4e29-aee6-ee99bcc00b1d/Group+Photo_Dec-2022_Nandos.jpg Lab Members - Make it stand out Group Lunch December 2022 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1631726806962-BJ1SXYP8WQB0JUCL4IFO/JWJ_Lab+Photo_1.jpg Lab Members Lab Photo 2020 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/3ae65c6e-7b12-4893-863d-5d0527795099/2024+ASMS+group+photo.jpg Lab Members - Make it stand out ASMS 2024 Anaheim, CA https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/7de8eb2f-edd1-43a1-88f9-f90324d26d06/ASMS-2023_Houston_group.jpg Lab Members - Make it stand out ASMS 2023 Houston, TX https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/ec1e1b88-5786-490a-9437-999d0746076f/lab+photo.PNG Lab Members - Make it stand out ASMS Conference on Mass Spectrometry 2021, Philadelphia, PA https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/74f8c61a-73e2-4c3d-aea1-bb703c2c3809/Group+Photo_Dec+2023_Nandos.jpg Lab Members - Make it stand out Group Lunch December 2023 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/838c15e4-d055-42f0-a297-90cd3b3fc19f/asms+2021.jpg Lab Members - Make it stand out ASMS 2021 Philadelphia, PA https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/a58387e1-a906-48b8-9ac8-f71b6d5abea4/thumbnail_Image.jpg Lab Members - Make it stand out Group Photo August 2022 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/848bc3e2-4d9a-45d4-82d1-fe21eb484f7b/GROUP+PIC.jpg Lab Members - Make it stand out Dr. Jones tenure celebration, Summer 2024 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1631727194437-WBD8X208C6T4SACWEMMI/IMG_1679.PNG Lab Members Group Photo Summer 2022 https://www.jacewjoneslab.com/overview daily 1.0 2025-05-21 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/639e832b-08ed-481b-b5c2-70c9bfbcc576/JWJ+Lab_Overview_05162025.jpg Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.jacewjoneslab.com/projects daily 0.75 2025-05-20 https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1631822618399-I2P6TFZZO6SM66O5B1NQ/1a.jpg Projects Sphingolipids (SPs) consist of a highly diverse class of lipids that function both as structural components of cellular membranes and signaling molecules eliciting apoptosis, proliferation, gene expression, and immune response. This project aims to comprehensively characterize SP structure and abundance by integrating chromatography, adduct formation, ion mobility, and tandem mass spectrometry. This multidimensional approach provides in-depth structural information such as acyl chain configuration, double bond location, and distinction of isomeric species. Further, we are anchoring structure to accurate quantitation. We are currently applying this approach to investigate the role SP metabolism plays as a molecular marker for hepatotoxicity in a drug-induced liver injury model system. https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1631823417867-H7LBMC35GR5BXX6NC9K7/1B.png Projects This project focuses on elucidating ether phospholipid dysregulation in neurodegenerative diseases such as traumatic brain injury (TBI). Due to their unique structure, ether phospholipids, specifically plasmalogen glycerophosphoethanolamine (PE), play a significant role in membrane dynamics, cell-cell interactions, and cellular signaling. Our research interests aim to understand how changes in PE composition can provide mechanistic insight into injury progression. We incorporate multidimensional approaches such as liquid chromatography, ion mobility, and tandem mass spectrometry to comprehensively evaluate changes to PE structure and abundance. Furthermore, we are interested in understanding how such changes may alter important organellular functions during TBI pathogenesis. https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/1631822668478-RW0A4P94GSL4HZS9085Y/1c.jpg Projects Lipids are important biomolecules in both the host cell and the pathogen. From a pathogenic perspective, lipids serve a protective role to safeguard against external pressures (e.g., harsh temperature or pH levels, and host immune defenses), and pathogenic lipids also play an active role in host recognition and subsequent entry into the host cell. Conversely, host cell lipids are vital to proper cell function and are at the forefront to the host’s cell response to interacting with a pathogen. We are interested in investigating the role lipids play at the interface of pathogenesis. This work is done by characterizing membrane lipids from enveloped viruses for identification of biomarkers to detect infections and as drug development targets. We are developing discovery and quantitative mass spectrometry methods to accomplish this work. https://images.squarespace-cdn.com/content/v1/5fdbb0c2f0445f6cf226660c/68ccf491-4140-47c1-85c8-99e3e05e309a/Capture.PNG Projects - Make it stand out Whatever it is, the way you tell your story online can make all the difference.